Endocrine Abstracts

One of the main consequences of vessel pruning and inhibition of neovessel growth produced by angiogenesis inhibitors is increased intra-tumor hypoxia. Nevertheless, growing evidence indicates that tumor cells escape from this hypoxic environment to better nourished locations, presenting hypoxia as a positive stimulus for invasion. Indeed, we and others have described a pro-invasive and pro-metastatic adaptation to VEGFR-targeted antiangiogenic therapy that implicates hypoxia ...

BackgroundIodine is an essential nutrient necessary for the synthesis of thyroid hormones. Humans need a daily intake of 90–250 µg per day. The WHO criteria on the adequate iodine intake in the general population is: median iodine 100–199 µg/l, levels <100 µg/l in <50% of the population; <50 µg/l in <20% of the population and iodized salt consumption in >90% of households.Objectives...